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2015). These studies, taken together, advise that, although a direct activation of GPR55 or PPAR‐α happens, PEA can develop its anti‐inflammatory motion from the intestine also by way of indirect activation of CB1 and CB2 receptors, most likely resulting from the ability of this compound to potentiate the action of endocannabinoids at these re

In this review, we focus on the molecular targets of PEA, its pharmacological exercise in neurological Problems, ache perception and inflammatory diseases, as well as the existing proof about the performance of micronized and extremely‐micronized formulations of PEA when provided alone or together While using the antioxidant flavonoids, which inc

PPAR‐α is really a nuclear receptor protein that belongs into the spouse and children of PPARs and acts as transcription element regulating gene expression (Issemann and Eco-friendly, 1990).Comprehension of exogenous PEA pharmacokinetics remains to be at an early phase [212]. Potential research must assess the precise tissue distribution and web